The 3-2-1 rule is the way to go – at least 3 copies of your data on at least 2 different media with at least 1 backup copy offsite.
What is “best” depends entirely on your specific circumstances and environment.
To expand on that, how much data needs to be backed up, how often you need to backup, how quickly you need to be able to recover your data, is it for backup only or also for redundancy to minimize downtime, etc.
At a minimum, every company should at least have onsite backups to some removable storage devices as well as a cloud backup system in place.
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